[Causes and factors of development of drug resistance in pulmonary tuberculosis]

To prevent secondary multidrug resistance and polyresistance of Mycobacterium tuberculosis (MBT), it is necessary to strictly observe the tested chemotherapy regimens during intensive care by using at least four essential antituberculous drugs (ATD) mainly in combination. The rehabilitative phase should be monitored at outpatient units of a day hospital. To prevent cross MBT infection with drug resistance to essential ATD and to efficiently use expensive reserve drugs, it is necessary to set up specialized inpatient units (wards) for treatment and rooms for outpatient receipt of patients who isolate drug-resistant MBT strains.