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Published on: April 6, 2022
Inhibition of nitrofurantoin reduction by menthol leads to enhanced antimicrobial activity
A R Shahverdi1, M R Fazeli, F Rafii
1Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences 14174, Tehran, Iran. shahverd@sina.tums.ac.ir
Abstract:
Nitrofurantoin is a nitroaromatic compound used for the treatment of urinary tract infections. Nitrofurantoin activity is regulated by a nitroreduction process. It is first reduced by bacterial nitroreductases to active short-life intermediates, which are further converted to non-toxic molecules, which negatively affect its antibacterial activity. In this study we have shown that resistant strains of Klebsiella sp. inactivate the bactericidal activity of nitrofurantoin. Also we demonstrated a synergistic effect between menthol and nitrofurantoin bactericidal activities against nitrofurantoin susceptible Enterobacteriaceae.
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