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Does circadian variation in risk factors for sudden infant death syndrome (SIDS) suggest there are two (or more) SIDS

E A Mitchell¹, S M Williams

¹Department of Paediatrics, University of Auckland, New Zealand. e.mitchell@auckland.ac.nz

Acta Paediatrica (Oslo, Norway : 1992)

|November 6, 2003

Abstract

Unlabelled:

Sudden infant death syndrome (SIDS) is known to occur more frequently at night. In two studies it has now been shown that a prone sleep position is more strongly associated with SIDS occurring during the day, whereas night-time deaths are more strongly associated with maternal smoking and illness.

Conclusion:

This variation, although unexplained, does suggest at least two SIDS subtypes: one related to sleep position and possibly a thermal mechanism, and one related to an uncontrolled inflammatory response to infection predominantly occurring at night. In addition, there are probably other mechanisms that do not show a circadian variation.

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