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Tolerance to early human milk feeding is not compromised by indomethacin in preterm infants with persistent ductus

M Bellander1, D Ley, S Polberger

  • 1Department of Paediatrics, University Hospital, Lund, Sweden.

Acta Paediatrica (Oslo, Norway : 1992)
|November 6, 2003
PubMed

Insights

Early human milk feeding is safe for preterm infants with persistent ductus arteriosus (PDA) treated with indomethacin. This feeding strategy shows good tolerance and comparable outcomes to controls, supporting its use in neonatal care.

Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Perinatology

Background:

  • Early human milk feeding is crucial for preterm infant gut and brain development.
  • Persistent ductus arteriosus (PDA) and its treatment with indomethacin can potentially affect enteral feeding tolerance.
  • Current practice often continues enteral milk feedings in preterm infants with PDA receiving indomethacin.

Purpose of the Study:

  • To evaluate the safety and tolerance of early enteral feeding with human milk in preterm infants treated with indomethacin for PDA.
  • To compare feeding outcomes and complications between preterm infants with PDA receiving indomethacin and matched controls.

Main Methods:

  • Retrospective study of 64 preterm infants (<29 wk gestational age).
  • 32 infants received indomethacin for symptomatic PDA (case group) and 32 were matched controls.
  • Comparison of gestational age, body weight, respiratory morbidity, feeding initiation, volumes, gastric residuals, and necrotizing enterocolitis rates.

Main Results:

  • No significant differences in the initiation of human milk feeding between case and control infants (median 4.0h vs 5.3h).
  • Similar feeding volumes and gastric residuals were observed in both groups during the first 7 days of life.
  • The incidence of necrotizing enterocolitis was comparable, with two cases in each group.

Conclusions:

  • Early enteral feeding with human milk, initiated within hours of birth, is well-tolerated in preterm infants undergoing indomethacin treatment for PDA.
  • This feeding strategy appears as safe and effective as in preterm infants without PDA requiring indomethacin.
  • Findings support the continuation of early human milk feeding in this vulnerable population.
Abstract

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