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Updated: Aug 30, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
2-Hydroxyflavanones from Leptospermum polygalifolium subsp. polygalifolium Equilibrating sets of hemiacetal isomers
Kamarul'Ain Mustafa1, Nigel B Perry, Rex T Weavers
1Department of Chemistry, University of Otago, PO Box 56, Dunedin, New Zealand.
Abstract:
2,5-Dihydroxy-6-methyl-7-methoxyflavanone and its isomer 2,5-dihydroxy-8-methyl-7-methoxyflavanone have been identified as the principal components in the ethanol extract of L. polygalifolium subsp. polygalifolium. The former compound has been separated from the latter for the first time by crystallisation. Other flavonoids identified include an equilibrating mixture of novel 2,3,5-trihydroxyflavanones; the first discovery of this type of compound from a natural source. This study has also confirmed the presence of the triketones, flavesone and leptospermone, along with the closely related isoleptospermone as anti-microbial components.
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