Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Excision repair--its bacterial beginnings.

James E Cleaver1

  • 1Auerbaok Melanoma Laboratory, UCSF Cancer Center, Room N431, University of California, PO Box 0808, San Francisco, CA 94143-0808, USA. jcleaver@cc.ucsf.edu

DNA Repair
|November 6, 2003
PubMed
Summary

Nucleotide excision repair, a DNA repair process, was discovered in 1964. This mechanism physically removes DNA damage like pyrimidine dimers, initiating the field of DNA repair.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockade.

The Journal of clinical investigation·2025
Same author

Bromodomain inhibition overcomes treatment resistance in distinct molecular subtypes of melanoma.

Proceedings of the National Academy of Sciences of the United States of America·2022
Same author

The UVSSA protein is part of a genome integrity homeostasis network with links to transcription-coupled DNA repair and ATM signaling.

Proceedings of the National Academy of Sciences of the United States of America·2022
Same author

Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation-Induced DNA Damage and Melanoma Susceptibility.

Cancer research·2021
Same author

Reappraisal of the prognostic significance of mitotic rate supports its reincorporation into the melanoma staging system.

Cancer·2020
Same author

Tumour predisposition and cancer syndromes as models to study gene-environment interactions.

Nature reviews. Cancer·2020

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • The discovery of DNA repair mechanisms is crucial for understanding genome stability.
  • Early research focused on identifying processes that counteract DNA damage.

Observation:

  • In 1964, Setlow and Carrier, and Boyce and Howard-Flanders independently reported a DNA repair system.
  • This system was observed to physically excise damaged DNA segments, specifically pyrimidine dimers.

Findings:

  • The identified repair process, nucleotide excision repair, removes DNA lesions.
  • Damaged DNA fragments were released as acid-soluble products, confirming physical removal.

Implications:

  • These foundational findings established the existence of DNA excision repair in bacteria.
  • This discovery paved the way for extensive research into DNA repair pathways and their significance in preventing mutations.

Related Experiment Videos