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Updated: Aug 30, 2026
Transient Transduction of the Strobilated Forms of Echinococcus granulosus
Published on: September 16, 2022
Identification of a gene engineering antibody against cystic echinococcosis in liver
Xin-Hua Chen1, Hao Wen, Yao-Xin Zhang
1Xinjiang Hydatid Clinical Research Institute, No.1 Liyushan Road, Urumqi 830054, China.
Objective:
To identify a gene engineering antibody against cystic echinococcosis in liver.
Methods:
A single chain of variable fragment of human antibodies (ScFvs) was selected from the library by using affinity selection technique with the recombinant antigen on solid surface. The positive clones were demonstrated by ELISA and their DNA sequences were also determined.
Results:
The DNA sequence data showed that the antibody gene is composed of 768 bp. In addition, a specific combination capacity with recombinant Echinococcus granulosus antigen B (r-EgB) was demonstrated by ELISA.
Conclusion:
The obtained gene engineering antibody against r-EgB may have potential implications in immunological treatment and drug targeting delivery.
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