Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone cancer pain.

Denis R Clohisy1, Patrick W Mantyh

  • 1Department of Orthopedic Surgery and Cancer Center, University of Minnesota, 420 Delaware Street SE, MMC 492, Minneapolis, MN 55455, USA. clohi001@tc.umn.edu

Clinical Orthopaedics and Related Research
|November 6, 2003
PubMed
Summary

Bone cancer pain arises from a unique mechanism involving nervous system sensitization. Osteoclastic bone resorption and the tumor itself are key contributors to this distinct pain state.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

5-fluoro-deoxyglucose PET/CT response after neoadjuvant chemotherapy predicts long-term outcomes in soft tissue sarcomas: Results from a prospective trial.

Cancer·2025
Same author

Multifocal Desmoid-Type Fibromatosis: Case Series and Potential Relationship to Neuronal Spread.

Cureus·2024
Same author

Multiple malignant tumors in a patient with familial chordoma, a case report.

BMC medical genomics·2021
Same author

Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats.

The Veterinary record·2018
Same author

Mechanisms that drive bone pain across the lifespan.

British journal of clinical pharmacology·2018
Same author

Anti-nerve growth factor does not change physical activity in normal young or aging mice but does increase activity in mice with skeletal pain.

Pain·2018

Area of Science:

  • Oncology
  • Pain Research
  • Animal Models

Background:

  • Bone cancer pain is a prevalent and challenging clinical issue.
  • Developing experimental models is crucial for understanding malignant disease pain mechanisms.

Purpose of the Study:

  • To investigate the mechanisms of bone cancer pain using a murine model.
  • To characterize the neurochemical changes associated with bone cancer pain.

Main Methods:

  • A murine model of distal femoral sarcoma was utilized.
  • Radiographs and histomorphometry assessed bone destruction.
  • Behavioral analysis and neurochemical profiling examined pain and sensitization.

Main Results:

  • Mice with bone cancer exhibited distinct behavioral and neurochemical pain indicators.
  • Bone cancer pain differed neurochemically from inflammatory and neuropathic pain.
  • Osteolysis and tumor presence contributed to pain, with evidence of peripheral and central sensitization.

Conclusions:

  • Malignant bone disease induces a unique pain state characterized by nervous system sensitization.
  • Osteoclastic bone resorption and the tumor are primary drivers of bone cancer pain.

Related Experiment Videos