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Updated: Aug 30, 2026

A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Longitudinal results of mandibular distraction osteogenesis in hemifacial microsomia
Clara E Huisinga-Fischer1, J Michiel Vaandrager, Birte Prahl-Andersen
1Department of Orthodontics, Academic Center for Dentistry, Amsterdam, The Netherlands. c.fischer@acta.nl
Abstract:
The aim of this study was to evaluate mandibular distraction therapy by three-dimensional (3-D) computed tomography (CT) imaging so as to be able to improve the treatment results. The study group consisted of eight children (3 male and 5 female) with hemifacial microsomia. For each child, CT scans of the head were available (Pro Speed S Fast Spiral scanner; General Electric). Longitudinal measurements of the mandible, bony and soft tissue 3-D reconstructions, and masticatory muscles were demonstrated. Three-dimensional CT scans provide important data concerning the results of mandibular distraction therapy and should be used in treatment evaluation. In some patients and for some muscles only, a small increase in the volume of the affected side of the masticatory muscles in comparison to the normal side was found 3 years after mandibular distraction. In around 50% of the cases, there seems to be a relapse occurring 1 year after distraction osteogenesis, and this relapse has a progressive character when seen 3 years after distraction osteogenesis in comparison to 15 weeks after distraction osteogenesis.

