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Updated: Aug 30, 2026
Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Verification of 99mTc-ethylenedicysteine (99mTc-EC) distribution model in the organism
1Department of Nuclear Medicine, Medical University of Łódź, Poland. zmnmjsur@psk2.am.lodz.pl
Background:
The aim of the present study was an attempt to verify the systemic distribution of 99mTC-ethylenedicysteine by means of the open two-compartment model.
Methods:
In order to accomplish this, 99mTc-EC clearance was determined in 21 patients as: two-compartmental model-based plasma clearance, and a urinary clearance, i.e. utilising the 99mTc-EC activity excreted with urine during a finite time interval.
Results:
There is a close correlation (r = 0.97) between the clearance values determined according to these two methods, and the rectilinear orthogonal correlation equation assumes a C1ECu = 1.03656C1ECp - 18.064 form. The slope of the line does not differ significantly from unity. The shift of the correlation line along the X-axis indicates a minor excretion of the radiopharmaceutical also by routes different from the urinary tract, e.g. with the bile.
Conclusions:
The performed comparison of the clearance values has proved that distribution of 99mTc-EC in the organism is consistent with the open two-compartment model.
