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Updated: Aug 30, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
Where are the prostate cancer genes?--A summary of eight genome wide searches
Douglas F Easton1, Daniel J Schaid, Alice S Whittemore
1Cancer Research U.K. Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom. douglas@srl.cam.ac.uk
Background:
There is strong evidence for genetic susceptibility to prostate cancer, but most of the genes underlying this susceptibility remain to be identified.
Methods:
We reviewed the results of eight genome-wide linkage searches based on 1,293 families with multiple cases of prostate cancer.
Results:
Across these studies, 11 linkage peaks with LOD scores in excess of 2 were identified. However, no chromosomal region was reported as significant at this level by more than one study and only one corresponded to a peak previously suggested by another group.
Conclusions:
These results indicate that prostate cancer is genetically complex, and that combined analyses of large family sets will be required to evaluate reliably the linkage evidence.
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