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[Aptameric DNA--a new type of thrombin inhibitor]
V A Spiridonova1, E V Rog, T N Dugina
1Belozersky Institute of Physicochemical Biology, Moscow State University, Vorob'evy gory, Moscow, 119992 Russia. spiridon@genebee.msu.su
Bioorganicheskaia Khimiia
|November 7, 2003
Abstract:
The formation of complexes between various thrombin preparations and a 30-mer aptamer DNA was comparatively studied, and a correlation between the complex formation and the fibrinogen-hydrolyzing activity of thrombin was found. The aptamer DNA was shown to inhibit the fibrin formation from fibrinogen.