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Published on: December 17, 2021
Ocular ethambutol toxicity
Alex Melamud1, Gregory S Kosmorsky, Michael S Lee
1Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Abstract:
Ethambutol is an antimicrobial agent used frequently to treat tuberculosis. The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature. We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol. This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.
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