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Azidopeptide nucleic acid. An alternative strategy for solid-phase peptide nucleic acid (PNA) synthesis
François Debaene1, Nicolas Winssinger
1Institut de Science et Ingénierie Supramoleculaires, Université Louis Pasteur, 8 allée Gaspard Monge, 67000 Strasbourg, France.
Organic Letters
|November 7, 2003
Abstract:
[reaction: see text] A practical and efficient method for PNA synthesis using an azide group to mask the N-terminus is reported. The deprotection was carried out in 5 min, while couplings were complete within 60 min. The near neutral conditions of the phosphine deprotection combined with the base-free coupling using hydroxybenzotriazole-activated monomers make this approach very mild.