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1-[2-(2-hydroxyalkyl)phenyl]ethanone: a new photoremovable protecting group for carboxylic acids
Walters N Atemnkeng1, Larry D Louisiana II, Promise K Yong
1Department of Chemistry, University of North Dakota, Grand Forks, North Dakota 58202-9024, USA.
Organic Letters
|November 7, 2003
Abstract:
[reaction: see text] A new photoremovable protecting group for carboxylic acids is introduced. The protecting group 1-[2-(2-hydroxyalkyl)phenyl]ethanone, HAPE, is used to protect various carboxylic acids. When photolyzed, the protected compound releases the acid in 70-85% isolated yields. The synthesis and the results of photorelease of the protected acids are presented here.