Future therapies for inflammatory bowel disease
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Updated: Aug 30, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
Published on: October 14, 2025
Stephen J Bickston1, Lawrence W Comerford, Fabio Cominelli
1University of Virginia Digestive Health Center of Excellence (UVA-DHCOE), MSB-2nd floor, Room 2121, Charlottesville, VA 22908-0708, USA. FC4Q@hscmail.mcc.virginia.edu
Abstract:
Three domains are accepted components of the etiology of inflammatory bowel disease (IBD): genetic predisposition, environmental stimuli, and abnormal immune response. The latter two are reasonable targets for medical therapies in the near future, whereas all three merit consideration for the more distant future as techniques of genetic manipulation evolve. In this review we summarize some of the fundamental concepts and offer comments on treatments for IBD that are likely and desirable in the near and distant future.
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