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Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
Published on: June 28, 2019
Cortical basal ganglionic degeneration
N Scarmeas1, S S Chin, K Marder
1College of Physicians and Surgeons of Columbia University, New York Presbyterian Hospital, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, the Sergievsky Center, New York, NY 12345, USA. ns257@columbia.edu
Abstract:
In this case study, we describe the symptoms, neuropsychological testing, and brain pathology of a retired mason's assistant with cortical basal ganglionic degeneration (CBGD). CBGD is an extremely rare neurodegenerative disease that is categorized under both Parkinsonian syndromes and frontal lobe dementias. It affects men and women nearly equally, and the age of onset is usually in the sixth decade of life. CBGD is characterized by Parkinson's-like motor symptoms and by deficits of movement and cognition, indicating focal brain pathology. Neuronal cell loss is ultimately responsible for the neurological symptoms.
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