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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
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Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

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Related Experiment Video

Updated: Jul 12, 2026

Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons
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Published on: October 30, 2018

Detangling Alzheimer's disease.

L Helmuth

    Science of Aging Knowledge Environment : SAGE KE
    |November 7, 2003
    PubMed
    Summary

    Researchers are investigating Alzheimer's disease (AD), a growing public health concern. Efforts focus on identifying genetic factors and early diagnostic methods to develop effective treatments for this neurodegenerative disorder.

    Area of Science:

    • Neuroscience
    • Genetics
    • Epidemiology

    Background:

    • Alzheimer's disease (AD) affects millions in the US, with projections indicating a significant increase due to an aging population.
    • The growing prevalence of AD necessitates urgent research into its underlying causes and effective management strategies.

    Purpose of the Study:

    • To identify genetic risk factors associated with Alzheimer's disease.
    • To elucidate the complex mechanisms driving AD pathogenesis.
    • To develop early diagnostic tools for timely intervention.

    Main Methods:

    • Genetic analysis to pinpoint risk factors.
    • Investigating neuropathological mechanisms in preclinical models.
    • Evaluating novel therapeutic strategies in clinical trials.

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    Related Experiment Videos

    Last Updated: Jul 12, 2026

    Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons
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    Published on: October 30, 2018

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    Main Results:

    • Ongoing research is identifying potential genetic contributors to AD.
    • Studies are advancing the understanding of AD-related neuropathology.
    • Novel therapeutic approaches are under investigation.

    Conclusions:

    • Continued research into genetic and mechanistic factors is crucial for combating Alzheimer's disease.
    • Developing early diagnostic tests is key to improving patient outcomes.
    • Novel therapeutic strategies show promise in preclinical models for stalling or reversing AD progression.