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Updated: Aug 2, 2026
On-Chip Endothelial Inflammatory Phenotyping
Published on: July 21, 2012
Circulating ICAM-1, VCAM-1, E-selectin, P-selectin, and TNFalphaRII in patients with coronary artery disease
M Hajilooi1, A Sanati, A Ahmadieh
1Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran.
Insights
Serum soluble intercellular adhesion molecule-1 (sICAM-1) is linked to coronary artery disease. Measuring sICAM-1 may enhance risk assessment for coronary artery disease in Iranian patients.
Area of Science:
- Cardiovascular Research
- Biomarker Discovery
- Inflammation and Atherosclerosis
Background:
- Coronary artery disease (CAD) involves complex inflammatory processes.
- Adhesion molecules play a crucial role in the pathogenesis of atherosclerosis.
Purpose of the Study:
- To investigate the association between serum levels of TNFalphaRII and adhesion molecules (ICAM-1, VCAM-1, P-selectin, E-selectin) with coronary artery stenosis.
- To determine the potential of these markers in predicting CAD risk.
Main Methods:
- Cross-sectional observational study involving 81 CAD patients and 75 controls.
- Enzyme-linked immunosorbent assay (ELISA) used to quantify serum soluble adhesion molecules and TNFalphaRII.
- Statistical analyses including logistic regression and multiple regression were performed.
Main Results:
- Significantly higher serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble P-selectin were observed in CAD patients compared to controls.
- sICAM-1 was identified as an independent risk factor for CAD.
- sP-selectin levels were elevated in patients with single-vessel disease.
Conclusions:
- Serum sICAM-1 is associated with stable coronary artery disease.
- sICAM-1 evaluation may improve coronary risk assessment, particularly in the Iranian population.
- Further research into adhesion molecules as CAD biomarkers is warranted.
Objective:
To evaluate the relationship between the serum concentration of TNFalphaRII and some adhesion molecules (including ICAM-1, VCAM-1, P-selectin and E-selectin) and coronary artery stenosis.
Design And Setting:
Observational (cross-sectional) study in a university heart hospital in Tehran, Iran.
Patients:
81 patients with angiographically proven coronary artery disease were compared with 75 individuals who had undergone coronary angiography with no significant evidence of stenosis (control subjects).
Methods:
Soluble adhesion molecules and TNFalphaRII were determined by enzyme-linked immunosorbent assay technique. sICAM-1 and sP-selectin values were significantly higher in patients with coronary artery disease than in control subjects (146 +/- 38 vs. 132 +/- 48 p < 0.04 and 275 +/- 107 vs. 241 +/- 104 ng/ml p < 0.04 respectively). Multiple logistic regression analysis showed sICAM-1 as an independent discriminating risk factor for coronary artery disease (p < 0.03). Prediction models that incorporated sICAM-1 in addition to other established coronary risk factors were significantly better at predicting risk than the models based on the other risk factors alone. Multiple regression analysis indicated that sP-selectin levels were greater in patients with single-vessel disease than in the respective normal (p < 0.01).
Conclusions:
Our findings suggest that sICAM-1 has an association with stable coronary artery disease and the evaluation of this marker may improve the coronary risk assessment in Iranian patients.
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