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Related Experiment Videos

Peritoneal function and assessment of reference values using a 3.86% glucose solution.

Watske Smit1, Paul van Dijk, Monique J Langedijk

  • 1Department of Nephrology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Wa.Smit@amc.uva.nl

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|November 8, 2003
PubMed
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This study establishes normal reference values for the peritoneal equilibration test (PET) using a 3.86% glucose solution, improving the detection of ultrafiltration failure (UFF) in peritoneal dialysis patients.

Area of Science:

  • Nephrology
  • Peritoneal Dialysis
  • Renal Function Testing

Background:

  • The standard peritoneal equilibration test (PET) uses 2.27% glucose.
  • A 3.86% glucose solution is recommended for enhanced sensitivity in detecting ultrafiltration failure (UFF).
  • Reference values for the 3.86% glucose PET were previously unavailable.

Purpose of the Study:

  • To analyze standard peritoneal permeability analyses (SPAs) using a 3.86% glucose solution.
  • To establish normal reference values for the PET with 3.86% glucose.
  • To aid in the analysis of UFF causes in peritoneal dialysis (PD) patients.

Main Methods:

  • 154 clinically stable PD patients, free of peritonitis for at least 4 weeks, underwent testing.
  • Two approaches were used for reference value assessment: excluding UFF patients (Approach A) and including only early PD patients (Approach B).

Related Experiment Videos

  • Transport parameters were calculated for 2.0-L and 1.5-L exchanges.

    • Main Results:

    • Reference values (means and 95% CI) were determined for parameters including MTAC creatinine, D/P creatinine, glucose absorption, Dt/D0 glucose, net UF, and D/P sodium dip.
    • Approach A provided specific reference ranges for these parameters.
    • Approach B showed similar transport values but significantly higher lymphatic absorption and lower D/P sodium dip, potentially due to UFF inclusion.

    Conclusions:

    • A peritoneal transport function test utilizing 3.86% glucose yields valuable data on transport characteristics.
    • This study provides essential normal reference values for the 3.86% glucose PET.
    • These reference values are crucial for diagnosing the causes of UFF in PD patients.