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Correlation between filling defect patterns on urography and pathologic staging of ureteral transitional cell
Yi-Lun Lee1, Shu-Pin Huang, Min-Chen Shih
1Department of Urology, Chi-Shan Hospital, Kaohsiung, Taiwan.
The Kaohsiung Journal of Medical Sciences
|November 8, 2003
Summary
Urographic filling defect patterns in ureteral transitional cell carcinomas (TCCs) correlate with disease advancement. Infiltrating and plaque-like TCC patterns indicate more advanced disease, aiding in treatment planning.
Area of Science:
- Urology
- Radiology
- Pathology
Background:
- Ureteral transitional cell carcinomas (TCCs) commonly present as filling defects on urography.
- The relationship between urographic filling defect patterns and the pathological characteristics of TCCs remains poorly understood.
Purpose of the Study:
- To investigate the correlation between different urographic filling defect patterns and the pathological findings of ureteral TCCs.
- To determine if filling defect morphology can predict disease invasiveness and stage.
Main Methods:
- A retrospective analysis of 126 pathologically confirmed ureteral TCCs diagnosed between 1995 and 2003.
- Classification of urographic filling defects into four patterns: ovoid, polypoid, infiltrating, and plaque-like.
- Statistical analysis using Pearson's Chi-squared and logistic regression to assess correlations.
Main Results:
- Ovoid defects (22%), polypoid defects (33%), infiltrating defects (29%), and plaque-like defects (15%) were identified.
- Infiltrating and plaque-like filling defects showed a significant association with more advanced disease (OR, 6.75; 95% CI, 3.04-14.98; p < 0.0001).
- Significant differences in defect pattern distribution were observed between superficial and advanced ureteral TCCs.
Conclusions:
- Urographic filling defect patterns in ureteral TCCs may indicate varying degrees of invasive behavior.
- Classification of these patterns can offer valuable preoperative information for treatment strategy and outcome prediction.