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A general strategy for the diastereoselective synthesis of 2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane lignans

David J Aldous1, Anne J Dalençon, Patrick G Steel

  • 1Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK.

The Journal of Organic Chemistry
|November 8, 2003
PubMed

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Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable, the...