Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Caveolin regulation of endothelial function.

Richard D Minshall1, William C Sessa, Radu V Stan

  • 1Department of Pharmacology, University of Illinois-Chicago Medical Center, Chicago, IL 60612, USA.

American Journal of Physiology. Lung Cellular and Molecular Physiology
|November 8, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wound Healing and Angiogenic Profiling of Dermal Endothelial Cells Isolated From People With Type 2 Diabetes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Effects of sevoflurane on natural killer cell-induced apoptosis of malignant tumour cells: an in vitro laboratory study.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same author

Transcriptomic profiling of the sex-linked biological pathways of severe pulmonary arterial hypertension associated with endothelial cell caveolin-1 depletion and chronic hypoxia.

Frontiers in physiology·2026
Same author

Innate Immune Function of Neutrophil Cytoplasts Generated Post-Vital NETosis.

Research square·2026
Same author

Age-Dependent Correlation of Pulmonary Function Impairment and Aortic Arch Stiffness in Mice.

Pediatric discovery·2026
Same author

Ubiquitin ligase CHFR impairs Tie2 signaling via K <sup>48</sup> -linked ubiquitylation and degradation of Akt1 in endothelial cells.

bioRxiv : the preprint server for biology·2026

Caveolin-1, a protein in cell membranes, regulates signaling and transport. Its absence causes cardiac and lung issues, highlighting its critical role in cell function and development.

Area of Science:

  • Cell biology
  • Molecular signaling
  • Endothelial function

Background:

  • Caveolae are specialized membrane domains concentrating signaling molecules.
  • Caveolin-1 is a key structural and regulatory protein within caveolae.
  • Caveolin-1's role in cellular processes is increasingly recognized.

Purpose of the Study:

  • To summarize the functions of caveolin-1 in cellular regulation.
  • To highlight caveolin-1's role in endothelial nitric oxide synthase (eNOS) signaling.
  • To review caveolin-1's involvement in transcytosis and calcium signaling.

Main Methods:

  • Review of recent studies on caveolin-1 function.
  • Analysis of gene deletion studies in mice.
  • Examination of caveolin-1 interactions with signaling molecules and transport processes.

Related Experiment Videos

Main Results:

  • Caveolin-1 stabilizes caveolae and regulates their internalization.
  • Caveolin-1 deletion in mice leads to cardiac hypertrophy and lung fibrosis.
  • Caveolin-1 inhibits endothelial nitric oxide synthase (eNOS) and regulates Ca2+ signaling.
  • Caveolin-1 phosphorylation is critical for transcytosis regulation.

Conclusions:

  • Caveolin-1 is essential for cardiac and lung development.
  • Caveolin-1 plays a multifaceted role in endothelial cell function, including signaling and transport.
  • Understanding caveolin-1 regulation is key to comprehending cellular homeostasis and disease.