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Updated: Aug 30, 2026
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Four cytotoxic N4-substituted thiosemicarbazones derived from 2-hydroxynaphthalene-1-carboxaldehyde
Paul V Bernhardt1, Lorraine M Caldwell, David B Lovejoy
1Department of Chemistry, The University of Queensland, Brisbane, Queensland 4072, Australia. p.bernhardt@uq.edu.au
Abstract:
The X-ray crystal structures are reported of four novel and potentially O,N,S-tridentate donor ligands that demonstrate antitumour activity. These ligands are 1-[(4-methylthiosemicarbazono)methyl]-2-naphthol, C(13)H(13)N(3)OS, (III), 1-[(4-ethylthiosemicarbazono)methyl]-2-naphthol, C(14)H(15)N(3)OS, (IV), 1-[(4-phenylthiosemicarbazono)methyl]-2-naphthol, C(18)H(15)N(3)OS, (V), and 1-[(4,4-dimethylthiosemicarbazono)methyl]-2-naphthol dimethyl sulfoxide solvate, C(14)H(15)N(3)OS.C(2)H(6)OS, (VI). These chelators are N4-substituted thiosemicarbazones, each based on the same parent aldehyde, namely 2-zhydroxynaphthalene-1-carboxaldehyde isonicotinoylhydrazone. Conformational variations within this series are discussed in relation to the optimum conformation for metal-ion binding.
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