[Intratympanic interval therapy of Menière disease with gentamicin with preserving cochlear function]

Area of Science:

• Otolaryngology
• Neurology
• Pharmacology

Context:

• Menière's disease is a chronic inner ear disorder.
• Intratympanic gentamicin injections are a common treatment.
• Optimizing gentamicin dosage is crucial for efficacy and safety.

Purpose:

• To evaluate the effectiveness and safety of a single-dose intratympanic gentamicin injection for Menière's disease.
• To determine the optimal timing and dosage for gentamicin treatment.
• To assess the impact of gentamicin on vertigo, tinnitus, and ear pressure.

Summary:

• A single intratympanic gentamicin injection (12 mg) was administered to 57 Menière's disease patients.
• Vertigo attacks were controlled in 95% of patients, with 50% achieving symptom resolution after one dose.
• Tinnitus and ear pressure improved in 46% and 69% of patients, respectively, with minimal hearing loss.

Impact:

• Single-dose intratympanic gentamicin therapy offers a simple, effective, and safe treatment for Menière's disease.
• This approach minimizes the risk of cochlear damage and preserves hearing.
• Early cessation of treatment upon observing inner ear reaction signs is key to preventing over-intoxication.