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[Living donor liver transplantation]
1Department of Transplantation and Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|November 8, 2003
Summary
Living donor liver transplantation (LDLT) has become a vital treatment for end-stage liver disease, overcoming initial challenges. This review highlights extensive experience, donor safety, recipient outcomes, and ongoing challenges in LDLT.
Area of Science:
- Hepatology and Transplant Surgery
- Organ Transplantation Research
- Surgical Innovation
Context:
- Liver transplantation is a standard treatment for end-stage liver disease.
- Organ shortages have driven the development of living organ donation.
- Living donor liver transplantation (LDLT) first occurred in 1988.
Purpose:
- To review extensive experience with living donor liver transplantation (LDLT) from a leading global program.
- To focus on donor safety, recipient outcomes, and complications in LDLT.
- To address persistent challenges and future directions in LDLT.
Summary:
- The Kyoto LDLT program, initiated in 1990, has performed over 900 transplantations, representing the oldest and largest in Japan.
- The review covers donor safety, post-LDLT results, and recipient complications.
- Unresolved issues such as graft size mismatching, venous drainage, LDLT for hepatocellular carcinoma, ABO-incompatible transplantation, and hepatitis C recurrence are discussed.
Impact:
- Provides insights into the long-term outcomes and safety of LDLT.
- Identifies critical areas for improvement in LDLT procedures and patient management.
- Informs future research and clinical practice for living donor liver transplantation worldwide.