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Pulmonary involvement in pediatric lymphoma

Katherine E Maturen1, Caroline E Blane, Peter J Strouse

  • 1Department of Radiology, University of Michigan Health Systems, 1500 E. Medical Center Drive/F3505, Ann Arbor, MI 48109-0030, USA.

Pediatric Radiology
|November 8, 2003
PubMed

Insights

Pulmonary lymphoma is more common in children with Hodgkin disease (HD), non-Hodgkin lymphoma (NHL), and post-transplant lymphoproliferative disorder (PTLD) than previously thought. This 13% prevalence highlights the need for vigilance in diagnosing lung involvement in pediatric lymphoma patients.

Area of Science:

  • Pediatric Oncology
  • Pulmonary Medicine
  • Radiology

Background:

  • Pulmonary lymphoma prevalence in pediatric patients is not well-documented.
  • Children with hematologic malignancies are at risk for extranodal disease.
  • Early identification of pulmonary involvement is crucial for treatment.

Purpose of the Study:

  • To determine the prevalence of pulmonary parenchymal lymphoma in children.
  • To assess involvement in Hodgkin disease (HD), non-Hodgkin lymphoma (NHL), and post-transplant lymphoproliferative disorder (PTLD).

Main Methods:

  • Retrospective analysis of 161 pediatric lymphoma patients over 10 years.
  • Defined pulmonary lymphoma excluding isolated pleural or mediastinal disease.
  • Utilized CT imaging findings for diagnosis.

Main Results:

  • Overall pulmonary parenchymal lymphoma prevalence was 13% (21/161).
  • Prevalence by subtype: 12% in HD, 10% in NHL, 29% in PTLD.
  • Common CT findings included nodules (90%), masses (38%), and interstitial disease (9%).

Conclusions:

  • Pediatric pulmonary lymphoma is more prevalent than expected, impacting patient management.
  • New pulmonary lesions in lymphoma patients warrant suspicion, especially in immunocompromised individuals.
  • Consider biopsy for lesions unresponsive to infection treatment to rule out lymphoma.
Abstract

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