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Plasma prolactin concentration increases after hypercapnia acidosis
S Rojas Vega1, H K Strüder, W Hollmann
1Institute for Movement Science in Individual Sports. rojas@dshs-koeln.de
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|November 8, 2003
Summary
This study found that plasma prolactin (PRL) levels increase after experiencing hypercapnia acidosis. This suggests that acidosis may stimulate central chemoreflexes, potentially influencing breathing and PRL release via serotonin pathways.
Area of Science:
- Physiology
- Endocrinology
- Respiratory Medicine
Background:
- Plasma prolactin (PRL) regulation is complex and influenced by various physiological stimuli.
- The impact of acute changes in blood gases and pH on PRL secretion requires further investigation.
Purpose of the Study:
- To investigate the effect of hypercapnia acidosis and hyperventilation on plasma prolactin concentrations in healthy males.
- To explore the potential role of central chemoreflexes and serotonergic pathways in mediating these responses.
Main Methods:
- Ten healthy males underwent two experimental conditions: 4 minutes of rebreathing (hypercapnia hyperoxia) and 4 minutes of voluntary hyperventilation.
- Capillary blood gases (pCO2, pH) and breathing frequency were monitored.
- Plasma PRL concentrations were measured before, during, and after each condition.
Main Results:
- Hypercapnia acidosis (increased pCO2, decreased pH) did not alter plasma PRL during the stimulus but led to a significant increase in PRL levels during the recovery period.
- Voluntary hyperventilation (decreased pCO2, increased pH) did not affect plasma PRL levels.
- Breathing frequency increased during recovery from hypercapnia acidosis.
Conclusions:
- Acute hypercapnia acidosis, but not hypocapnia, is associated with a delayed increase in plasma prolactin.
- Acidosis-induced central chemoreflex activation, potentially mediated by serotonergic pathways, may contribute to both increased breathing and PRL release.