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Tablets of functionalized polystyrene beads alone and in combination with solid reagents or catalysts. Preparation
Thomas Ruhland1, Per Holm, Kim Andersen
1Department of Medicinal Chemistry II, Medicinal Chemistry Research, H. Lundbeck A/S, 9 Ottiliavej, DK 2500 Valby, Denmark. tr@lundbeck.com
Abstract:
Pretreatment of polystyrene beads with a nonpolar organic solvent is the key for the generation of mechanically robust tablets consisting of neat functionalized polystyrene beads, both alone and in combination with solid reagents or catalysts. The novel dosing methodology provides accurately preweighed tablets in virtually any shape and size and with excellent disintegration properties, speeding up parallel solution and solid phase synthesis. The use of tablets is demonstrated in parallel Mitsunobu and acylation reactions.
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