Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroleptic malignant syndrome.

M S Jahan1, A I Farooque, Z Wahid

  • 1Department of Psychiatry, Meharry Medical College, Nashville, TN 37208.

Journal of the National Medical Association
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Some Stories are Yet Not Over: Experiences of Neonatal Tetanus from a Tertiary Care Hospital, Bangladesh.

Mymensingh medical journal : MMJ·2026
Same author

Free Flap Reconstruction in Head and Neck Surgery: Experience in Bangabandhu Sheikh Mujib Medical University.

Mymensingh medical journal : MMJ·2021
Same author

Nitrous Oxide versus Medical Air Using in General Anaesthesia During Laparoscopic Cholecystectomy: A Comparative Study.

Mymensingh medical journal : MMJ·2020
Same author

A Case Study on Chronic Hepatitis-C Viral infection Associated with Hepatocellular Carcinoma in a Tertiary Hospital of Bangladesh.

Mymensingh medical journal : MMJ·2019
Same author

Effect of moisture, lipids, and select amino acid blocking agents on the formation and stability of metastable radicals in powdered soy proteins.

Journal of food science·2012
Same author

Effects of packaging environments on free radicals in gamma-irradiated UHMWPE resin powder blend with vitamin E.

Journal of biomedical materials research. Part A·2008
Same journal

Perioperative outcomes: Transforming healthcare.

Journal of the National Medical Association·2026
Same journal

The intersection of infectious diseases and cardiovascular disease in Africa: A narrative review.

Journal of the National Medical Association·2026
Same journal

Atrial fibrillation in chronic heart failure: prevalence and one-year outcome in the Ibadan chronic heart failure project.

Journal of the National Medical Association·2026
Same journal

Corrigendum to ``Medical student perspectives of leadership development in community engagement'' [In Press].

Journal of the National Medical Association·2026
Same journal

Ethno-racial trauma and well-being in medical education: A scoping review of U.S. physician trainees and medical students.

Journal of the National Medical Association·2026
Same journal

Cuts to medicaid and the affordable care act: Negative consequences for the black community.

Journal of the National Medical Association·2026
See all related articles

Neuroleptic malignant syndrome (NMS) is a severe reaction to neuroleptic drugs, potentially fatal. Early recognition and careful patient monitoring are crucial for reducing NMS incidence and mortality.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Medicine

Background:

  • Neuroleptic malignant syndrome (NMS) is a rare but life-threatening adverse reaction to neuroleptic medications.
  • It affects an estimated 1% to 1.5% of patients treated with neuroleptics, with reported mortality rates ranging from 11% to 38%.

Observation:

  • NMS risk factors include younger males (under 40) and physical disability.
  • While 80% of cases develop within the first two weeks of treatment, NMS can occur at any point during therapy.
  • Clinical presentation and laboratory findings are often non-specific, with less than 50% of cases exhibiting classical symptoms.

Findings:

  • Cardiovascular collapse is the most common cause of death in NMS.
  • Other reported complications include renal failure, pulmonary emboli, aspiration pneumonia, and respiratory failure.

Related Experiment Videos

  • Diagnosis relies on clinical suspicion, baseline laboratory values (CPK, LDH, SGOT, CBC), and familiarity with the syndrome.

    • Implications:

    • Prompt diagnosis and management are critical for improving patient outcomes.
    • Judicious selection of neuroleptic medications and vigilant patient observation can mitigate NMS incidence, morbidity, and mortality.