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Related Experiment Videos

Accessibility of solid core tablet for dissolution in an asymmetric triple-layer matrix system.

Libo Yang1, Reza Fassihi

  • 1Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA 19140, USA. lyang@icos.com

The Journal of Pharmacy and Pharmacology
|November 11, 2003
PubMed
Summary

Zero-order drug release kinetics were achieved using barrier layers in triple-layer tablets. Barrier layer thickness and composition control the duration of linear drug release, influenced by polymer properties and drug accessibility.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Achieving constant drug release is crucial for effective therapeutic outcomes.
  • Zero-order release kinetics, ensuring consistent drug levels, are highly desirable in pharmaceutical formulations.

Purpose of the Study:

  • To investigate the role of glassy matrix surface area in maintaining constant drug release.
  • To determine the effect of barrier layer thickness on the duration of linear release in asymmetric triple-layer tablets.
  • To elucidate the mechanisms controlling drug release, specifically diffusion and polymer relaxation.

Main Methods:

  • Utilized an asymmetric triple-layer tablet design with Poly(ethylene oxide) and hydroxypropylmethylcellulose K4M.
  • Employed verapamil hydrochloride as a model drug.
  • Analyzed drug release data using non-linear regression to differentiate diffusion and polymer relaxation contributions.

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Main Results:

  • Barrier layers on the central core tablet facilitated polymer relaxation as the primary drug release mechanism.
  • Zero-order release kinetics were successfully achieved.
  • The duration of linear release was found to be dependent on barrier layer thickness and composition.
  • Drug release mechanisms were influenced by drug core accessibility and polymer swelling/erosion properties.

Conclusions:

  • Asymmetric triple-layer tablets with barrier layers can effectively achieve zero-order drug release kinetics.
  • Controlling barrier layer characteristics is key to modulating the duration of linear drug release.
  • Understanding the interplay between diffusion, polymer relaxation, and formulation properties is essential for designing controlled-release drug delivery systems.