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Related Experiment Videos

In utero herpes simplex encephalitis.

Anna Lee1, Naor Bar-Zeev, Susan P Walker

  • 1Department of Obstetrics and Gynecology, Mercy Hospital for Women and University of Melbourne, Victoria, Australia.

Obstetrics and Gynecology
|November 11, 2003
PubMed
Summary
This summary is machine-generated.

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Transplacental herpes simplex virus infection during pregnancy is a rare but lethal complication. It can lead to overwhelming fetal sepsis and brain death, highlighting the need for prompt diagnosis.

Area of Science:

  • Reproductive Medicine
  • Infectious Diseases
  • Neonatology

Background:

  • Herpes simplex virus (HSV) infection during pregnancy, particularly primary infection, can lead to transplacental transmission.
  • This rare complication can result in severe fetal sepsis and multiorgan failure, including fetal brain death.

Observation:

  • A 34-year-old multigravida presented with a genital herpes simplex lesion at 16 weeks gestation.
  • At 28 weeks gestation, she reported no fetal movements; delivery revealed an infant with disseminated herpes simplex type 2 infection.

Findings:

  • Postmortem examination confirmed disseminated herpes simplex type 2 infection in the neonate.
  • The case illustrates the potential for overwhelming in utero sepsis from transplacental HSV.

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Implications:

  • Transplacental herpes simplex is a rare, potentially lethal form of congenital herpes.
  • Clinicians should consider overwhelming in utero sepsis in the differential diagnosis of fetal brain death.