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Related Experiment Video

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Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model

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[Clinical examination of acetated Ringer solution in patients with normal liver function and those with liver

T Isosu¹, Y Akama, C Tase

¹Department of Anesthesiology, Fukushima Medical College.

Masui. the Japanese Journal of Anesthesiology

|November 1, 1992

Summary

Acetated Ringer solution (AR) and lactated Ringer solution (LR) are equally useful intraoperative fluids, even in patients with liver dysfunction. Neither solution demonstrated superiority in this clinical study.

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Area of Science:

Clinical Medicine
Anesthesiology
Gastroenterology

Background:

Intraoperative fluid management is critical, especially in patients with compromised liver function.
Acetated Ringer solution (AR) and lactated Ringer solution (LR) are commonly used intravenous fluids.
The metabolic impact of AR and LR in patients with liver dysfunction requires further clinical investigation.

Purpose of the Study:

To compare the clinical usefulness and metabolic effects of AR versus LR in patients undergoing surgery.
To assess the influence of liver dysfunction on the metabolism of AR and LR during intraoperative fluid administration.

Main Methods:

A clinical study involving 38 surgical patients divided into four groups based on liver function (normal vs. dysfunction) and infused fluid (AR vs. LR).
Fluid administration at a rate of 10 ml.kg-1.h-1.
Monitoring of acid-base balance, electrolytes, liver function, and specific acid metabolites (L-lactic acid, D-lactic acid, acetic acid).

Main Results:

L-lactic acid increased significantly in all groups following AR or LR infusion.
D-lactic acid levels rose in LR groups, while acetic acid increased in AR groups.
No significant changes were observed in acid-base balance, electrolytes, or liver function across all groups, indicating liver dysfunction did not impact lactic acid metabolism.

Conclusions:

Acetated Ringer solution (AR) is clinically as useful as lactated Ringer solution (LR) for intraoperative fluid management.
No significant differences were found between AR and LR in terms of metabolic changes or clinical outcomes.
AR is not demonstrably superior to LR as an intraoperative fluid, even in patients with liver dysfunction.