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Quadrupole mass filters with octopole fields.

Chuanfan Ding1, N V Konenkov, D J Douglas

  • 1Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T 1Z1, Canada.

Rapid Communications in Mass Spectrometry : RCM
|November 11, 2003
PubMed
Summary
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Adding octopole fields to quadrupole mass filters significantly enhances ion resolution. This study demonstrates high mass resolution (5800) by strategically applying direct current (dc) to specific rods, challenging previous assumptions in mass spectrometry.

Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Physical Chemistry

Background:

  • Quadrupole mass filters (QMFs) typically aim to minimize higher-order multipoles for high resolution.
  • Conventional QMFs achieve resolution limited by mechanical tolerances and construction errors.
  • Previous literature suggests higher-order multipoles degrade mass resolution.

Purpose of the Study:

  • To investigate the performance of QMFs with intentionally added octopole fields.
  • To determine the effect of octopole field strength on mass resolution.
  • To explore the impact of dc voltage polarity on ion resolution in QMFs.

Main Methods:

  • Construction of quadrupole rod sets with added octopole fields using rods of differing diameters.
  • Experimental investigation of positive and negative ion resolution with varying dc voltage polarities.

Related Experiment Videos

  • Numerical simulations of ion peak shapes and stability region boundaries.

    • Main Results:

    • A resolution of 5800 at half height was achieved for positive ions with a 2.6% octopole field by applying positive dc to smaller rods.
    • Negative ion resolution was optimized with reversed dc polarity (negative dc to smaller rods).
    • Simulations confirmed experimental findings, showing well-defined stability regions with optimal dc application.

    Conclusions:

    • Intentionally added octopole fields can dramatically improve mass resolution in QMFs, contrary to prior expectations.
    • Strategic application of dc voltage polarity is crucial for optimizing resolution in these modified QMFs.
    • These modified rod sets offer potential for improved performance in instruments requiring both linear trapping and mass filtering capabilities.