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Updated: Aug 30, 2026
A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
Published on: February 23, 2018
[Influence of the indometafen radioprotector on the immune reactivity]
P P Mikhaĭlov1, V N Mal'tsev, T G Shliakova
1State Research Center-Institute of Biophysics, Russian Ministry of Health, Moscow, 123182 Russia.
In the experiments on dogs and mice it was shown that indometophene could modify the immune status of the body. Specific and non-specific resistance of mice to E. coli infection increased after indometophene administration. At the same time higher titers of normal anti-salmonella antibodies in mice serum and a higher phagocytic activity of neutrophils in the peripheral blood in dogs were found. The influence of the preparation on the content of the complement and normal antibodies-hemagglutinins was less pronounced. It was suggested that the indometophene ability to bustle immune reactivity of the body played a certain role in the mechanism of its radioprotective effect.
In the experiments on dogs and mice it was shown that indometophene could modify the immune status of the body. Specific and non-specific resistance of mice to E. coli infection increased after indometophene administration. At the same time higher titers of normal anti-salmonella antibodies in mice serum and a higher phagocytic activity of neutrophils in the peripheral blood in dogs were found. The influence of the preparation on the content of the complement and normal antibodies-hemagglutinins was less pronounced. It was suggested that the indometophene ability to bustle immune reactivity of the body played a certain role in the mechanism of its radioprotective effect.
