Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene expression in muscle in response to exercise.

Geoffrey Goldspink1

  • 1Molecular Tissue Repair Unit, Department of Surgery, Royal Free and University College Medical School, Royal Free Campus, University of London, Rowland Hill Street, London NW3 2PF, UK. g.goldspink@rfc.ucl.ac.uk

Journal of Muscle Research and Cell Motility
|November 12, 2003
PubMed
Summary

Mechanical growth factor (MGF) activates muscle satellite cells for repair and hypertrophy. Its decline in aged and dystrophic muscles contributes to muscle mass loss.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechano-Growth Factor: an important cog or a loose screw in the repair machinery?

Frontiers in endocrinology·2012
Same author

Age-related loss of muscle mass and strength.

Journal of aging research·2012
Same author

Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages.

Mechanisms of ageing and development·2011
Same author

A proteomic approach combining MS and bioinformatic analysis for the detection and identification of biomarkers of administration of exogenous human growth hormone in humans.

Proteomics. Clinical applications·2010
Same author

Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. Counterpoint: IGF is not the major physiological regulator of muscle mass.

Journal of applied physiology (Bethesda, Md. : 1985)·2010
Same author

Growth factors, muscle function, and doping.

Endocrinology and metabolism clinics of North America·2010

Area of Science:

  • Muscle physiology and adaptation
  • Molecular biology of muscle growth
  • Cellular mechanisms of muscle repair

Background:

  • Muscle adapts to work by altering fiber type and mass through gene expression changes.
  • Insulin-like growth factor I (IGF-I) splice variants, including MGF and IGF-IEa, play roles in muscle adaptation.
  • MGF is linked to mechanical stimulation, satellite cell activation, and muscle repair.

Purpose of the Study:

  • To investigate the role of MGF in muscle adaptation, repair, and hypertrophy.
  • To explore the regulation and function of MGF compared to IGF-IEa.
  • To understand the impact of aging and muscular dystrophy on MGF expression and satellite cell activation.

Main Methods:

  • Cloning of three IGF-I splice variants in human muscle.

Related Experiment Videos

  • Analysis of MGF expression following mechanical stimulation.
  • Comparison of MGF and IGF-IEa expression kinetics and signaling pathways.
  • Investigation of MGF expression in dystrophic and aged muscle models.

    • Main Results:

    • MGF, an autocrine/paracrine splice variant, is induced by mechanical stimulation.
    • MGF activates mononucleated myoblasts (satellite cells) and promotes muscle repair and hypertrophy.
    • MGF expression declines with aging and is impaired in dystrophic muscle.
    • The dystrophin complex may be involved in MGF mechanotransduction.

    Conclusions:

    • MGF is a key local mediator of muscle repair and hypertrophy in response to mechanical load.
    • Deficient MGF expression and satellite cell activation contribute to muscle mass loss in aging and muscular dystrophy.
    • MGF represents a distinct growth factor with unique signaling properties compared to systemic IGF-IEa.