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Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins
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Report of three children with leptospirosis in rural area of the east of Turkey.

Muhammed Güzel Kurtoğlu1, Oğuz Tuncer, Hamza Bozkurt

  • 1Department of Microbiology, Yuzuncu Yil University School of Medicine, Van, Turkey.

The Tohoku Journal of Experimental Medicine
|November 12, 2003
PubMed
Summary

Leptospirosis is a significant public health concern in rural Eastern Turkey, particularly affecting children. Early consideration of this bacterial infection is crucial for prompt diagnosis and treatment in pediatric patients presenting with specific symptoms.

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Area of Science:

  • Infectious Diseases
  • Pediatrics
  • Microbiology

Background:

  • Leptospirosis is a zoonotic bacterial disease with significant morbidity, often presenting with severe systemic symptoms.
  • Risk factors include occupational exposure in agricultural settings and contact with infected animals.

Observation:

  • Three pediatric cases of leptospirosis in Eastern Turkey are presented, aged 10–13 years.
  • Key symptoms included headache, fever, fatigue, abdominal pain, and unconsciousness.
  • Clinical manifestations involved hepatic, renal, pulmonary, and possibly pericardial systems.

Findings:

  • Spirochetes were identified in blood and urine via dark-field microscopy.
  • Leptospira were successfully cultured from blood and urine using Flecher medium.
  • Penicillin was the primary treatment; one patient required additional antibiotics for secondary Klebsiella pneumoniae septicemia.

Implications:

  • Leptospirosis remains a public health issue in rural agricultural regions of Eastern Turkey.
  • Clinicians should consider leptospirosis in children presenting with fever, headache, abdominal pain, and altered consciousness.
  • Prompt diagnosis and appropriate treatment are essential for favorable outcomes, though treatment completion is vital.