Voltammetric and HPLC techniques for the determination of paroxetine hydrochloride

The antidepressant agent paroxetine hydrochloride (POT) was studied by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and osteryoung square wave voltammetry (OSWV). A sensitive method is described for the determination of POT in its pure form and in human plasma. The linear relationship between concentration and peak current permits the quantification of POT by CV, DPV and OSWV in the concentration range of 2 x 10(-5) - 8 x 10(-4) M. Applicability to tablets and human plasma analysis has been illustrated. Furthermore, a HPLC method with diode array detection was developed. Linearity was established between 2 x 10(-7) - 6 x 10(-5) M for POT. The described methods were successfully employed with high degrees of precision and accuracy for the estimation of total drug content in human plasma and pharmaceutical dosage forms of POT.