Effect of atorvastatin on exercise-induced myocardial ischemia in patients with stable angina pectoris
Peter Bogaty1, Gilles R Dagenais, Paul Poirier
1Quebec Heart Institute, Laval Hospital, Ste-Foy, Quebec, Canada. peter.Bogaty@med.ulaval.ca
Abstract:
To investigate whether marked and sustained lipid-lowering in subjects with stable angina pectoris and dyslipidemia reduces exercise-induced myocardial ischemia, 17 subjects were treated with dose-adjusted atorvastatin over 1 year and underwent serial evaluation of exercise electrocardiographic ischemic parameters, serum biomarkers, and brachial artery endothelial function. Endothelial function improved progressively and C-reactive protein, P-selectin, and tissue plasminogen activator inhibitor levels decreased, but there was no decrease in exercise electrocardiographic ischemia.
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