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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Left ventricular dyssynchrony predicts benefit of cardiac resynchronization therapy in patients with end-stage heart
Jeroen J Bax1, Thomas H Marwick, Sander G Molhoek
1Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. jbax@knoware.nl
Abstract:
We evaluated patients with end-stage heart failure who have a high likelihood of response to cardiac resynchronization therapy (biventricular pacing). It appears that 20% of patients do not respond to this expensive therapy despite the use of selection criteria (dilated cardiomyopathy, heart failure, New York Heart Association class II or IV, left ventricular ejection fraction <35%, left bundle branch block, and QRS >120 ms). The presence of left ventricular dyssynchrony is needed to result in improvement after cardiac resynchronization therapy.
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