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Updated: Aug 30, 2026

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
Published on: May 9, 2025
[Cellular immunotherapy: complexity of immune system and industrial development]
1IDM, Institut de recherches biomédicales des Cordeliers, Université Pierre et Marie Curie, 15, rue de l'Ecole-de Médecine, 75006 Paris, France. jpabas@idm-biotech.com
Abstract:
Cell immunotherapy aims at treating patients by stimulating their own immune system using appropriate cells. This approach is one of the most promising therapeutic strategy against cancer. The use of cells, the mobilization of a system, the targeting of interactions between the immune system and the tumor constitute the hallmarks of complexity, an area of intense academic and industrial research during the past twenty years. The present article reviews some unique characteristics of the industrial development of these cell drugs.
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