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Updated: Aug 30, 2026

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
Published on: November 22, 2024
Impaired hemodynamics and neural activation? A fMRI study of major cerebral artery stenosis
M Hund-Georgiadis1, T Mildner, D Georgiadis
1Max-Planck-Institute of Cognitive Neuroscience, Leipzig, Germany. hund@cns.mpg.de
Abstract:
Functional MRI motor mapping was performed in two women with unilateral high-grade stenosis of the middle cerebral artery (MCA) to determine the influence of impaired hemodynamics on the blood oxygenation level dependent (BOLD) response. In both patients no structural lesions were present in primary motor pathways. A redistribution of the motor network to the healthy hemisphere was the main indicator of chronic hemodynamic compromise.
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