Rheological studies on precursor cells at different stages in mice

The deformability and membrane fluidity of the precursor cells for mice at different growth stages were studied; and it was found that the deformability and membrane fluidity were increased with the growth of the precursor cells. It is demonstrated that the normoblast was just placed in a turning point in the growth stage of the precursor cells. The changes are associated with the smaller the nucleus, the smaller the ratio of nucleus and cytoplasm, and the expression of membrane skeleton protein, and so on. It is also found that the order parameter (S) obtained by ESR is negatively correlated with the small deformation index (DI)(d,max) obtained by LBY-BX2 ektacytometer, while the value of R2 (square of correlation coefficient) is 0.9816. Such conclusion shows that the order parameter (S) is basically in accordance with the small deformation index (DI)(d,max).