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Updated: Aug 30, 2026
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Determinants of prostate cancer specific survival following radiation therapy during the prostate specific antigen
Anthony V D'Amico1, Kerri Cote, Marian Loffredo
1Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, MA 02215, USA. adamico@lroc.harvard.edu
Purpose:
Identifying pretreatment and posttreatment predictors of time to prostate cancer specific death (PCSD) following external beam radiation therapy (RT) is the subject of this study.
Materials And Methods:
A Cox regression analysis was used to evaluate the ability of the pretreatment risk group to predict time to PCSD for 381 patients who underwent RT for clinically localized prostate cancer. Posttreatment factors analyzed for the 94 patients who experienced prostate specific antigen (PSA) failure included the time to failure, posttreatment PSA doubling time (DT) and timing of salvage hormonal therapy.
Results:
Despite a median age of 73 at diagnosis, 45% of patients with high risk disease were estimated to die of prostate cancer within 10 years following RT compared to 0% (p = 0.004) and 6% (p = 0.05) of those with low or intermediate risk disease, respectively. Predictors of time to PCSD following PSA failure included PSA DT (p = 0.01) and delayed use of hormonal therapy (p
Conclusions:
Prostate cancer was a major cause of death during the first decade following RT for patients with clinically localized but high risk disease, and the cause of death for patients with a short PSA DT following RT was nearly always prostate cancer. These data provide evidence to propose the hypothesis that a short posttreatment PSA DT may serve as a possible surrogate for PCSD. Prospective validation is needed.
