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[Therapy of viral hepatitis]

B Burckhardt1, J Reichen

  • 1Institut für Klinische Pharmakologie, Universität Bern. beat.burckhardt@ikp.unibe.ch

Therapeutische Umschau. Revue Therapeutique
|November 13, 2003
PubMed

Insights

Current treatments for chronic viral hepatitis B and C offer moderate success rates. While therapies can reduce liver disease progression, challenges like viral resistance and relapse persist, necessitating further research for improved outcomes.

Area of Science:

  • Hepatology
  • Virology
  • Internal Medicine

Background:

  • Chronic viral hepatitis B and C are major global causes of liver disease, including cirrhosis and cancer.
  • Effective management is crucial to prevent severe hepatic complications.

Purpose of the Study:

  • To review current therapeutic strategies for chronic hepatitis B and C.
  • To discuss practical considerations and outcomes of these treatments.

Main Methods:

  • Review of existing literature on therapies for chronic viral hepatitis B and C.
  • Analysis of treatment efficacy, indications, and practical aspects.

Main Results:

  • Hepatitis C treatment with pegylated interferon and ribavirin achieves viral eradication in approximately 55% of patients.
  • Hepatitis B treatment with interferon alpha yields HBe antigen seroconversion in 25-45% and HBs antigen loss in ~10%.
  • Lamivudine shows promise for anti-HBe positive hepatitis B but faces challenges with relapse and resistance.

Conclusions:

  • Current therapies for chronic viral hepatitis B and C can slow disease progression to cirrhosis and cancer in responders.
  • Further advancements are needed to overcome limitations such as viral resistance and high relapse rates in hepatitis B treatment.

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