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Changes in probe sensitivity during NMR spectroscopic studies of the perfused rat heart: a warning
J F Nédélec1, J K Saunders, P Morris
1Institute for Biological Sciences, National Research Council, Ottawa, Ontario, Canada.
Magnetic Resonance in Medicine
|October 1, 1992
Abstract:
During NMR experiments on isolated, perfused rat heart, we observed a 57% change in probe sensitivity when the perfusion buffer surrounding the heart was replaced by either a low-ionic-strength mannitol solution or air and the heart was made ischemic. Such changes in sensitivity, should they go unrecognized, would result in substantial quantification errors.