Concentration-independent spontaneously forming biomimetric vesicles
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Updated: Aug 30, 2026

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting
Published on: February 21, 2014
M-P Nieh1, T A Harroun, V A Raghunathan
1National Research Council, Steacie Institute for Molecular Sciences, Chalk River, Ontario, K0J 1J0, Canada.
Abstract:
In this Letter we present small-angle neutron scattering data from a biomimetic system composed of the phospholipids dimyristoyl and dihexanoyl phosphorylcholine (DMPC and DHPC, respectively). Doping DMPC-DHPC multilamellar vesicles with either the negatively charged lipid dimyristoyl phosphorylglycerol (DMPG, net charge -1) or the divalent cation, calcium (Ca2+), leads to the spontaneous formation of energetically stabilized monodisperse unilamellar vesicles whose radii are concentration independent and in contrast with previous experimental observations.
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