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Updated: Aug 30, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
Cage amines as the stopper inhibitors of cholinesterases
Gialih Lin1, Hou-Jen Tsai, Yi-Hon Tsai
1Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan. gilin@dragon.nchu.edu.tw
Abstract:
Cage amines 1-4 are potent peripheral anionic site-bound reversible inhibitors of both acetylcholinesterase and butyrylcholinesterase. Cage amines 1-3 are selective butyrylcholinesterase inhibitor versus acetylcholinesterase. For both enzymes, the -log K(i) values linearly correlate with the difference of substituted phenyl radius of cage amines (-log K(i)=5.4+3.4Deltagamma for acetylcholinesterase, -log K(i)=5.9+3.2Deltagamma for butyrylcholinesterase). Moreover, the relationship between the enzymes and cage amines mimics that between bottles and stoppers.
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