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Updated: Aug 30, 2026

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
Published on: April 18, 2015
MR dynamic Gadolinium-enhanced fast multiplanar spoiled gradient-echo and spin-echo T1-weighted fat-suppressed
Meng-Su Zeng1, Fu-Hua Yan, Kang-Rong Zhou
1Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. zmswq@public4.sta.net.cn
Objective:
To evaluate the value of MR dynamic Gadolinium-enhanced fast multiplanar spoiled gradient-echo (FMPSPGR) and spin-echo (SE) T1-weighted fat-suppressed techniques in the diagnosis of pancreatic carcinoma.
Methods:
Eighteen cases of pancreatic carcinoma verified by surgical and pathologic results were examined by MR, and the MR sequences included SE T1WI, FSE T2WI, SE T1-weighted fat-suppressed and dynamic Gadolinium-enhanced FMPSPGR.
Results:
Of 18 pancreatic carcinomas, 10, 6, and 2 tumors showed respectively hypo-intensity, iso-intensity and hyper-intensity on SE T1WI, meanwhile, 8, 6, and 4 tumors displayed hyper-intensity, iso-intensity and hypo-intensity on FSE T2WI in comparison with the normal pancreatic tissue. All of the tumors showed hypo-intensity on SE T1-weighted fat-suppressed and also obvious non-enhancement or slight enhancement on MR dynamic Gadolinium-enhanced FMPSPGR images during the arterial dominant phase scanning.
Conclusion:
SE T1-weighted fat-suppressed and MR dynamic Gadolinium-enhanced FMPSPGR sequences could evidently improve the sensitivity and specificity in the diagnosis of pancreatic carcinoma.
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Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
