Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Visceral afferent pathways and functional brain imaging.

Stuart W G Derbyshire1

  • 1Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. derbyshiresw@anes.upmc.edu

Thescientificworldjournal
|November 13, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral contributions to offset analgesia: effects of stimulus duration, intensity, and location.

Pain·2025
Same author

The Hope and Reality of Pain Relief Using Psychological Manipulations.

Psychosomatic medicine·2024
Same author

Offset analgesia is reduced on the palm and increases with stimulus duration.

European journal of pain (London, England)·2020
Same author

Stepwise increasing sequential offsets cannot be used to deliver high thermal intensities with little or no perception of pain.

Journal of neurophysiology·2019
Same author

Suggestions to Reduce Clinical Fibromyalgia Pain and Experimentally Induced Pain Produce Parallel Effects on Perceived Pain but Divergent Functional MRI-Based Brain Activity.

Psychosomatic medicine·2016
Same author

Distinct BOLD fMRI Responses of Capsaicin-Induced Thermal Sensation Reveal Pain-Related Brain Activation in Nonhuman Primates.

PloS one·2016

Functional imaging reveals distinct brain activation patterns for somatic versus visceral pain. However, differences in brain activity between irritable bowel syndrome (IBS) patients and controls remain unclear.

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Pain Research

Background:

  • Functional pain disorders, like irritable bowel syndrome (IBS), are increasingly studied using functional imaging.
  • Understanding brain dysfunction is key to explaining conditions like IBS.

Purpose of the Study:

  • To review functional imaging findings in somatic and visceral pain processing.
  • To explore hypotheses on brain-gut axis dysfunction in IBS patients.

Main Methods:

  • Review of recent functional imaging studies on pain processing.
  • Comparison of brain activation patterns for somatic and visceral noxious stimuli.
  • Analysis of brain activity differences in IBS patients versus controls.

Main Results:

Related Experiment Videos

  • Visceral distension (especially lower GI) activates affect and autonomic response brain regions.
  • Somatic pain activates cognition and skeletomotor response brain regions.
  • Brain activation differences between IBS patients and controls were not clearly interpretable.

Conclusions:

  • Functional imaging shows distinct neural pathways for different pain types.
  • Current understanding of IBS and functional imaging limitations hinder clear patient-specific findings.
  • Future research requires defined theoretical and clinical endpoints for success in functional disorders.